A selection of references from BioSyntha staff.

1. Burgos, A.; Caille, J-C.; Gradley, M.L. WO2008/ 2911603. Procedure for the enzymatic chemoselective hydrolysis of a diester for the preparation of a monoester monoacid.

2. Burgos A, Caille JC, Gradley ML, Frein S, Derrien Y & Chenard E WO2007/132119. In situ or one-pot hydrogenation and reductive amination method.

3. Gradley, M.L., Trivett, A.J., Willets, A.J., Chatakondu, K., Robins, K.G., Cheetham, P.S.J., Walls, M., Alston, M.J. WO2007/0205655. Flavour product.

4. Gradley, M.L., Willetts, A.J., Sime,J.T. WO2000/ 0047758. Methods of making compounds.

5. Cheetham, P.S.J., Gradley, M.L. and Sime, J.T. WO2000/0050622. Flavour/ aroma materials and their preparations.

6. Gradley, M.L., Deverson, C.J.F. and Knowles, C.J. (1994). Asymmetric hydrolysis of R-(-),S-(+) -2-methylbutyronitrile by Rhodococcus rhodochrous NCIMB11216. Arch. Microbiol. 161, 246-251.

7. Gradley, M.L. and Knowles C.J. (1994). Asymmetric hydrolysis of chiral nitriles by Rhodococcus rhodochrous NCIMB 11216. Biotechnol Letts 16, 41-46.

8. Todd M, Drake CS, Rudd BAM, Roberts DW, Clarkson-Jones J, Booth M, Lenz E, Phillips P & Dawson MJ (2005) Biotrans 2005 Poster Presentation. Metabolite Factories: use of microbial systems to generate metabolites of ZD4054, an endothelin receptor antagonist.

9. Cripps RE, Eley K, Leak DJ, Rudd B, Tay;or M, Todd M, Boakes S, Martin S & Atkinson T (2009) Metabolic Engineering 11, 398 – 408. Metabolic engineering of Geobacillus thermoglucosidasius for high yield ethanol production.

10. Atkinson A, Cripps R, Rudd B, Eley K, Martin S, Milner P & Mercier C WO2008/038019. Thermophilic microorganisms for ethanol production.

11. Atkinson A, Cripps R, Thompson A, Eley K, Taylor M, Leak D, Rudd B & Baker S WO2006/131734. Modified microorganisms with inactivated lactate dehydrogenase gene.

12. Atkinson A, Cripps R, Eley K, Rudd B & Todd M WO2006/117536. Thermophilic microorganisms with inactivated lactate dehydrogenase gene (LDH) for ethanol production.

13. Dawson MJ, Cortes J, Rudd BAM, Boakes S, Bierbaum G, Hoffmann A & Schmitz S WO2005/093069. Production of Mersacidin and its Variants in ∆SigH and/or ∆MrsA Bacillus Host Cells.

14. Boakes S, Oliynyk M, Cortes J, Bohm I, Rudd BA, Revill WP, Staunton J, Leadlay PF. (2004) J Mol Microbiol Biotechnol. 8, 73-80. A new modular polyketide synthase in the erythromycin producer Saccharopolyspora erythraea.

15. Del Vecchio F, Petkovic H, Kendrew SG, Low L, Wilkinson B, Lill R, Cortes J, Rudd BA, Staunton J, Leadlay PF. (2003) J Ind Microbiol Biotechnol. 30, 489-94. Active-site residue, domain and module swaps in modular polyketide synthases.

16. Milne C, Harvey B, Gordon L, Borg M, Flett F, Wilkinson B, Sidebottom PJ, Rudd BA, Hayes MA, Smith CP, Micklefield J (2002) Chem Biol. 9, 1175-87. Structure, Biosynthetic Origin, and Engineered Biosynthesis of Calcium-Dependent Antibiotics from Streptomyces coelicolor.

17. Nicholson TP, Rudd BAM, Dawson M, Lazarus CM, Simpson TJ & Cox RJ (2001) Chem. Biol. 8, 157-178. Design and utility of oligonucleotide gene probes for fungal polyketide synthases

18. Rowe CJ, Bohm IU, Thomas IP, Wilkinson B, Rudd BAM, Foster G, Blackaby A, Sidebottom PJ, Roddis Y, Buss AD, Staunton J & Leadlay PF (2001) Chem. Biol. 8, 475-485. Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase.

19. Holzbaur IE, Ranganathan A, Thomas IP, Kearney DJA, Reather JA, Rudd BAM, Staunton J & Leadlay PF (2001) Chem. Biol. 8, 329-340. Molecular basis of Celmer’s rules: role of the ketosynthase domain in epimerisation and demonstration that ketoreductase domains can have altered product specificity with unnatural substrates.

20. Nicholson TP, Rudd BAM, Dawson M, Lazarus CM, Simpson TJ & Cox RJ (2001) Chem. Biol. 8, 157-178. Design and utility of oligonucleotide gene probes for fungal polyketide synthases.

21. Wilkinson B, Foster G, Rudd BAM, Blackaby AP, Sidebottom PJ, Cooper DJ, Dawson MJ, Buss AD, Gaisser S, Bohm IU, Rowe CJ, Cortes J, Leadley PF & Staunton J (2000) Chem. Biol. 7, 111-117. Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase

22. Holzbaur IE, Harris RC, Bycroft M, Cortes J, Bisang C, Staunton J, Rudd BAM & Leadlay PF (1999) Chem. Biol. 6, 189-195. Molecular basis of Celmer’s rules: the role of two ketoreductase domains in the control of chirality by the erythromycin modular polyketide synthase

23. Hopwood DA, Malpartida F, Kieser HM, Ikeda H, Duncan J, Fujii I, Rudd BAM, Floss HG & Omura S (1985) Nature 314, 642-644. Production of ‘hybrid’ antibiotics by genetic engineering.

24. Boakes S, Cortes J, Appleyard AN, Rudd BAM & Dawson MJ (2009) Molecular Microbiology 72, 1126 – 1136. Organization of the genes encoding the biosynthesis of actagardine and engineering of a variant generation system.

25. Appleyard AN, Choi S, Read DM, Lightfoot A, Boakes S, Hoffmann A, Chopra I, Bierbaum G, Rudd BAM, Dawson MJ & Cortes J (2009) Chemistry & Biology 16, 490 – 498. Dissecting structural and functional diversity of the lantibiotic mersacidin.

26. Schmitz S, Hoffmann A, Szekat C, Rudd B & Bierbaum G (2006) Appl. Environ. Microbiol. 72, 7270- 7277. The lantibiotic mersacidin is an autoinducing peptide.